Major risk factors for ischemic cardiovascular and cerebrovascular disease are:

• Diabetes mellitus
• Hypertension
• Central obesity: waist circumference ≥ 94 cm (men) and ≥ 80 cm (women)
• Dyslipidemia (fasting levels): Total cholesterol > 5 mmol/L, or LDL> 3 mmol/L, or HDL< 1 mmol/L in men and < 1.2 mmol/L in women
• Smoking
• Age: Men > 50 years, Women > 60 years
• Family history of early onset cardiovascular disease; Male relatives < 55 years and Female relatives < 65 year

Estimation of total cardiovascular risk is important for prevention of CVD in an individual, should be adapted to his or her total CV risk: the higher the risk, the more intense the management should be.

For Cardiovascular Disease Risk Classification

Very High Risk

Subjects with any of the following:

Documented CVD, clinical or unequivocal on imaging: Documented clinical CVD includes previous AMI, ACS, coronary revascularization and other arterial revascularization procedures, stroke and TIA, aortic aneurysm and PAD.

Unequivocally documented CVD on imaging includes plaque on coronary angiography or carotid ultrasound. It does NOT include some increase in continuous imaging parameters such as intima–media thickness of the carotid artery.

DM with target organ damage such as proteinuria or with a major risk factor such as smoking or marked hypercholesterolaemia or marked hypertension.

• Severe CKD (GFR <30 mL/min/1.73 m²).
• A calculated CVD Risk Score ≥10%.

High Risk

Subjects with:

• Markedly elevated single risk factors, in cholesterol >8 mmol/L (>310 mg/dL) (e.g. in familial hypercholesterolaemia) or BP ≥180/110 mmHg.
• Most other people with DM (except for young people with type 1 DM and

Without major risk factors that may be at low or moderate risk).

• Moderate CKD (GFR 30–59 mL/min/1.73 m²).
• A calculated CVD Risk Score ≥5% and <10%.

Moderate Risk

CVD Risk Score is ≥1% and <5% at 10 years. Many middle–aged subjects belong to this category

Low Risk

CVD Risk Score < 1%