Fixed Drug Eruption (FDE)
Introduction
It is a cutaneous drug reaction that recurs at exactly the same site with repeated exposure to the agent.
Signs & symptoms
• Typically red-brown patch or plaque
• Occasionally may be bullous
• Most common sites are genitalia, palms, and soles, as well as mucosa
• Lesions are typically 5–10cm in diameter but can be larger
• Often multiple. Starts with edematous papule or plaque later becomes darker
• Resolves with post-inflammatory hyperpigmentation
Diagnostic criteria
• Typically red-brown patch or plaque
• Occasionally may be bullous
• Most common sites are genitalia, palms, and soles, as well as mucosa
• Lesions are typically 5–10cm in diameter but can be larger
• Often multiple. Starts with edematous papule or plaque later becomes darker
• Resolves with post-inflammatory hyperpigmentation
Note: When confronted with hyper pigmented macule on genitalia, always think of Fixed Drug Eruption
Investigation
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Treatment
-
Non-Pharmacological treatment
- Avoidance of triggering agent;
• Use of topical corticosteroids may speed resolution
-
Pharmacological
- • Systemic corticosteroid, eg Prednisolone or Hydrocortisone
• Topical corticosteroid (as in eczemas)
• Oral antihistamines
Prevention
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Updated on,
3 Novemba 2020 12:36:44
References
- 1.STG