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Small cell lung cancer
Introduction
SCLC is characterized by early development of widespread of metastases. It is highly sensitive to initial chemotherapy and radiotherapy; however, most patients eventually die of recurrent disease.
Signs and Symptoms
Diagnostic criteria
As in non – small cell lung cancer (NSCLC) however brain scan and bone marrow aspirate are necessary \
Staging: Limited disease versus extensive disease
Investigation
Treatment
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Pharmacological
- Aim is for local control and palliation. Cure rate is low Platinum + Etoposide are the major drugs for which the tumor is sensitive.
• Cisplatin IV 60 mg/m2 Day 1 + Etoposide IV 100 mg/m2 Day1–3 , Every 3 weeks for 4 –6 cycles
OR
• Carboplatin IV AUC 5 Day 1 + Etoposide IV 100 mg/m2 Day1–3, every 3 weeks for 4–6 cycles Other available active drugs include irinotecan and gemcitab
Radiotherapy:
Consolidation to primary site and mediastinum: 50Gy/25F/5weeeks
• Prophylactic brain irradiation in complete responders
• Temporary relief of respiratory, bone or CNS symptoms: 30Gy/10F/2wks
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Non-pharmacological
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Prevention
Updated on,
5 Novemba 2020 12:18:19
References
1.STG
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