By ULY CLINIC

Amoebic Liver Abscess

Introduction

It is the most frequent extra-intestinal manifestation of Entamoeba histolytica infection which results from the invasion of the portal venous system from the colon leading to inflammation and subsequently abscess formation particularly involving the right lobe of the liver.

Diagnostic Criteria

High grade fever
Right upper quadrant pain,
Tender and enlarged liver
Positive imaging evidence of liver abscess

AND

Serological evidence of E. histolytica antibodies or antigens.

Pharmacological Treatment

Metronidazole IV 800 mg, 8 hourly for 10 days.

Tinidazole (PO). Adults: 2g once daily for 3 days

Note:

Metronidazole, Tinidazole, and Secnidazole should not be given in the first trimester of pregnancy due to potential teratogenic effects.

Should not be taken with alcohol due to disulfiram like effects Surgery: Abscess cavity (size >5 cm in diameter) not regressing despite 7 days treatment should be aspirated.

Updated on, 2.11.2020

References

1. STG

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Amoebic Liver Abscess

Introduction

Diagnostic Criteria

Pharmacological Treatment

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