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Aplastic Anaemia (Bone Marrow Failure)

Aplastic anaemia is defined as pancytopenia resulting from aplasia of the bone marrow.


Pancytopenia – a reduction in the blood count of all the major cell lines


Causes of aplastic anaemia

Aplastic anemia causes-ulyclinic

Clinical Features

Vary with severity but include;

  • Anaemia

  • Easy bruising/bleeding

  • Recurrent infection


Note-splenomegaly is not a feature. 

Diagnostic Criteria

Pancytopenia- Bone marrow hypocellularity of < 30% hematopoietic cells for children and young adults; confirmed by trephine biopsy. 

Classification by severity of Aplastic Anaemia (AA) 

Severe AA (SAA)  


For SAA at least two of the following three criteria have to be fulfilled:

  • Reticulocytes <60x109/L (using an automated analyzer)  or < 20 x 109/l (manual count)

  • Platelets < 20x109/L

  • Absolute neutrophils <0.5 x109/L

Very severe AA (vSAA)

For vSAA, the same criteria of SAA have to be fulfilled; however the absolute neutrophil count has to be < 0.2 x109/l 

Moderate Aplastic Anaemia (AA)

Moderate AA is considered when the severity criteria of SAA are not fulfilled

Updated on, 6.11.2020


1. STG

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