By ULY CLINIC

Aplastic Anaemia (Bone Marrow Failure)

Aplastic anaemia is defined as pancytopenia resulting from aplasia of the bone marrow.

Pancytopenia – a reduction in the blood count of all the major cell lines

Causes of aplastic anaemia

Clinical Features

Vary with severity but include;

Note-splenomegaly is not a feature.

Pancytopenia- Bone marrow hypocellularity of < 30% hematopoietic cells for children and young adults; confirmed by trephine biopsy.

Classification by severity of Aplastic Anaemia (AA)

For SAA at least two of the following three criteria have to be fulfilled:

Reticulocytes <60x109/L (using an automated analyzer) or < 20 x 109/l (manual count)
Platelets < 20x109/L
Absolute neutrophils <0.5 x109/L

For vSAA, the same criteria of SAA have to be fulfilled; however the absolute neutrophil count has to be < 0.2 x109/l

Moderate AA is considered when the severity criteria of SAA are not fulfilled

Updated on, 6.11.2020

References

1. STG