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Mwandishi:

Dkt. Sospeter M, MD

Mhariri:

Dkt. Lugonda B, MD

28 Machi 2021 09:51:20

Dawa Rifapentine

Dawa Rifapentine

Ni dawa ya antibiotic jamii ya macrolactams, inayotumika katika matibabu ya TB, dawa hii huzuia kimeng’enya polymerase kufanya kazi katika utengenezaji wa DNA ya baadhi ya seli isipokuwa seli za wanyama. Dawa hii huwa maarufu kwa jina jingine la priftin

Uzito na fomu ya rifapentine


Dawa hii hupatikana kama kidonge chenye uzito wa gramu 150

Matumizi ya rifapentine


Hutumika kwa ajili ya matibabu ya Kifua kikuu. Kwa sababu ya kuzuka kwa usugu wa vimelea wa maradhi kwenye dawa, dawa hii imeachwa kutumika kutibu maambukizi ya mycobacterial wanaosababisha kifua kikuu.

Namna rifapentine inavyofanya kazi


Huzuia kimeng’enya cha polymerase kianchofanya kazi ya kuzalisha DNA, kiungo muhimu cha seli ya bakteria. Kwa kufanya hivi huzuia uzalianaji wa bakteria. Dawa hii ina uwanja mkubwa wa kutibu maambukizi ya bakteria wa gramu chanya na gramu hasi ikiwa pamoja na bakteria Pseudomonas aeruginosa na haswa Mycobacterium tuberculosis.

Kutokana na ufanyaji kazi wake, dawa hii huzuia utengenezaji na pia kuua bakteria ambao wameshatengenezwa’

Ufyonzaji wa dawa rifapentine


Dawa hii hufyonzwa haraka mara inapoingia kwenye mfumo wa chakula

Vimelea wanaodhuriwa na rifapentine

Mycobacterium tuberculosis

Mycobacterium avium complex

Mwingiliano wa rifapentine na chakula


Rifapentine ni nzuri endapo itatumiwa pamoja na chakula, kwani chakula huongeza ufyonzwaji wa dawa hii. Ili kupunguza maudhi ya dawa kwenye mfumo wat umbo, inashauriwa itumike pamoja na chakula. Unaweza kupasua kidonge na kuchanganya na chakula au uji mzito kisha kunywa.

Wagonjwa wasiopaswa kutumia rifapentine

Wagonjwa wenye mzio na dawa jamii ya rifamycin hawapaswi kutumia dawa hii

Utoaji taka wa rifapentine mwilini


Asilimia 87 ya dawa hutolewa kwa njia ya mkojo, na asilimia zinazobaki hutoka kwa njia ya haja kubwa.

Matumizi ya rifapentine kwa mama mjamzito


Kwa maelezo zaidi soma kwenye Makala ya madhara rifapentine katika ujauzito ndani ya tovuti ya ULY CLINIC

Matumizi ya rifapentine wakati wa kunyonyesha


Haifahamiki zaidi endapo dawa hii inaingia kwenye maziwa ya mama na hivyo kumpata mtoto. Hata hivo dawa hii hufanya maziwa yaonekane kuwa na rangi ya machungwa. Kwa maelezo zaidi soma kwenye Makala ya madhara rifapentine wakati wa kunyonyesha ndani ya tovuti ya ULY CLINIC

Mwingiliana wa rifapentine na dawa zingine


Mwingiliano mkali hazipaswi kutumika pamoja na rifapentine


  • Abemaciclib

  • Acalabrutinib

  • Alpelisib

  • Apremilast

  • Artemether/lumefantrine (ALU)

  • Atazanavir

  • Avapritinib

  • Axitinib

  • Bedaquiline

  • Bictegravir

  • Bosutinib

  • Brigatinib

  • Cabozantinib

  • Cariprazine

  • Ceritinib

  • Chanjo hai ya BCG

  • Chanjo ya taifodi

  • Cobimetinib

  • Copanlisib

  • Dabrafenib

  • Darolutamide

  • Darunavir

  • Deflazacort

  • Dienogest/estradiol valerate

  • Dihydroergotamine

  • Dihydroergotamine ya kuweka puani

  • Doravirine

  • Dronedarone

  • Duvelisib

  • Elbasvir/grazoprevir

  • Eliglustat

  • Elvitegravir

  • Elvitegravir/cobicistat/emtricitabine/tenofovir DF

  • Erdafitinib

  • Ergotamine

  • Erythromycin base

  • Erythromycin ethylsuccinate

  • Erythromycin lactobionate

  • Erythromycin stearate

  • Ethinylestradiol

  • Etravirine

  • Everolimus

  • Fedratinib

  • Fosamprenavir

  • Fostamatinib

  • Fostemsavir

  • Glasdegib

  • Ibrutinib

  • Idelalisib

  • Indinavir

  • Irinotecan

  • Irinotecan liposomal

  • Istradefylline

  • Ivabradine

  • Ivacaftor

  • Ivosidenib

  • Ixazomib

  • Larotrectinib

  • Ledipasvir/sofosbuvir

  • Lefamulin

  • Lemborexant

  • Lonafarnib

  • Lorlatinib

  • Lovastatin

  • Lumacaftor/ivacaftor

  • Lumefantrine

  • Lurasidone

  • Lurbinectedin

  • Macimorelin

  • Macitentan

  • Mestranol

  • Midostaurin

  • Naldemedine

  • Naloxegol

  • Nelfinavir

  • Neratinib

  • Netupitant/palonosetron

  • Norethindrone

  • Norethindrone acetate

  • Norethindrone ya kuchoma kwenye ngozi

  • Olaparib

  • Ombitasvir/paritaprevir/ritonavir & dasabuvir

  • Osimertinib

  • Ozanimod

  • Palbociclib

  • Panobinostat

  • Pemigatinib

  • Perampanel

  • Pexidartinib

  • Pomalidomide

  • Ponatinib

  • Pralsetinib

  • Praziquantel

  • Pretomanid

  • Ranolazine

  • Regorafenib

  • Rilpivirine

  • Rimegepant

  • Ripretinib

  • Ritonavir

  • Roflumilast

  • Rolapitant

  • Romidepsin

  • Saquinavir

  • Selumetinib

  • Silodosin

  • Simvastatin

  • Siponimod

  • Sirolimus

  • Sofosbuvir

  • Sofosbuvir/velpatasvir

  • Sonidegib

  • Stiripentol

  • Tazemetostat

  • Tepotinib

  • Tezacaftor

  • Tipranavir

  • Tivozanib

  • Tolvaptan

  • Trabectedin

  • Trazodone

  • Tucatinib

  • Ubrogepant

  • Ulipristal

  • Upadacitinib

  • Valbenazine

  • Vandetanib

  • Vemurafenib

  • Venetoclax

  • Vorapaxar

  • Voxelotor

  • Zanubrutinib


Rifapentine ikitumika na dawa hizi, mgonjwa anatakiwa kuwa chini ya uangalizi wa karibu


  • Abiraterone

  • Alitretinoin

  • Almotriptan

  • Alprazolam

  • Amiodarone

  • Amitriptyline

  • Amlodipine

  • Aprepitant

  • Aripiprazole

  • Atorvastatin

  • Avanafil

  • Avatrombopag

  • Bazedoxifene/conjugated estrogens

  • Benzhydrocodone/acetaminophen

  • Bexarotene

  • Bortezomib

  • Brentuximab vedotin

  • Brexpiprazole

  • Budesonide

  • Buprenorphine

  • Buprenorphine a kuweka mdomoni

  • Buprenorphine, a kufanya kazi muda mrefu

  • Buspirone

  • Cabazitaxel

  • Calcifediol

  • Cannabidiol

  • Carbamazepine

  • Carvedilol

  • Chlorpropamide

  • Cilostazol

  • Cinacalcet

  • Clobetasone

  • Clomipramine

  • Clopidogrel

  • Clozapine

  • Colchicine

  • Conivaptan

  • Conjugated estrogens

  • Conjugated estrogens, a kuweka kwenye uke

  • Cortisone

  • Crizotinib

  • Cyclosporine

  • Darifenacin

  • Darunavir

  • Dasatinib

  • Desipramine

  • Dexamethasone

  • Diazepam

  • Diazepam a kuweka puani

  • Digoxin

  • Diltiazem

  • Dronabinol

  • Elagolix

  • Eletriptan

  • Eltrombopag

  • Erlotinib

  • Estradiol

  • Estradiol vaginal

  • Estrogens conjugated synthetic

  • Estrogens esterified

  • Estropipate

  • Ethotoin

  • Etonogestrel

  • Etoposide

  • Etravirine

  • Exemestane

  • Felodipine

  • Fentanyl

  • Fentanyl intranasal

  • Fentanyl transdermal

  • Fentanyl transmucosal

  • Fesoterodine

  • Flibanserin

  • Fludrocortisone

  • Fosamprenavir

  • Fosphenytoin

  • Gefitinib

  • Glecaprevir/pibrentasvir

  • Glimepiride

  • Glipizide

  • Glyburide

  • Guanfacine

  • Hydrocodone

  • Hydrocortisone

  • Hydroxyprogesterone caproate

  • Ifosfamide

  • Iloperidone

  • Imipramine

  • Indinavir

  • Ixabepilone

  • Lapatinib

  • Lesinurad

  • Levamlodipine

  • Levonorgestrel intrauterine

  • Levonorgestrel oral

  • Levonorgestrel oral/ethinylestradiol/ferrous bisglycinate

  • Linagliptin

  • Lopinavir

  • Loratadine

  • Losartan

  • Maraviroc

  • Medroxyprogesterone

  • Mestranol

  • Methadone

  • Methylprednisolone

  • Metoprolol

  • Midazolam

  • Mifepristone

  • Nateglinide

  • Nelfinavir

  • Nevirapine

  • Nicardipine

  • Nifedipine

  • Nilotinib

  • Nisoldipine

  • Oliceridine

  • Osilodrostat

  • Ospemifene

  • Oxycodone

  • Paclitaxel

  • Paclitaxel protein bound

  • Parecoxib

  • Pazopanib

  • Phenytoin

  • Pimavanserin

  • Pitolisant

  • Polatuzumab vedotin

  • Prednisolone

  • Prednisone

  • Propranolol

  • Quetiapine

  • Quinidine

  • Repaglinide

  • Ribociclib

  • Riociguat

  • Ritonavir

  • Saquinavir

  • Selexipag

  • Sildenafil

  • Sodium picosulfate/magnesium oxide/anhydrous citric acid

  • Solifenacin

  • Sorafenib

  • Sufentanil sl

  • Sunitinib

  • Suvorexant

  • Tacrolimus

  • Tadalafil

  • Tamoxifen

  • Tasimelteon

  • Temsirolimus

  • Terbinafine

  • Theophylline

  • Ticagrelor

  • Tinidazole

  • Tipranavir

  • Tofacitinib

  • Tolazamide

  • Tolbutamide

  • Tolterodine

  • Toremifene

  • Tramadol

  • Triamcinolone acetonide injectable suspension

  • Triazolam

  • Vardenafil

  • Verapamil

  • Vilazodone

  • Voriconazole

  • Vortioxetine

  • Warfarin

Dawa hizi zinamwingiliano mdogo na rifapentine


  • Alfentanil

  • Alfuzosin

  • Alosetron

  • Ambrisentan

  • Armodafinil

  • Atazanavir

  • Bosentan

  • Buprenorphine a kupandikiza chini ya ngozi

  • Celecoxib

  • Cevimeline

  • Clarithromycin

  • Dapsone

  • Diclofenac

  • Disopyramide

  • Docetaxel

  • Donepezil

  • Doxorubicin

  • Doxorubicin liposomal

  • Dutasteride

  • Efavirenz

  • Eplerenone

  • Eucalyptus

  • Finasteride

  • Flurbiprofen

  • Fluvastatin

  • Galantamine

  • Ibuprofen

  • Ibuprofen iv

  • Imatinib

  • Isradipine

  • Itraconazole

  • Ketoconazole

  • Lansoprazole

  • Meloxicam

  • Montelukast

  • Nimodipine

  • Nitrendipine

  • Ondansetron

  • Oxybutynin

  • Paclitaxel

  • Paclitaxel protein bound

  • Parecoxib

  • Pimozide

  • Pioglitazone

  • Piroxicam

  • Propafenone

  • Quinine

  • Rabeprazole

  • Ramelteon

  • Saxagliptin

  • Sufentanil

  • Sulfamethoxazole

  • Tolbutamide

  • Vinblastine

  • Vincristine

  • Vincristine liposomal

  • Vinorelbine

  • Voriconazole

  • Zaleplon

  • Ziprasidone

  • Zolpidem

  • Zonisamide

Maudhi madogo ya rifapentine


  • Kuongezeka kwa kiwango cha uric acid kwenye damu

  • Kuongezeka kwa shinikizo la damu

  • Maumivu ya kichwa

  • Kizunguzungu

  • Muwasho

  • Chunusi

  • Kuishiwa hamu ya kula

  • Kuharisha

  • Kiungulia

  • Upungufu wa neutrophil

  • Upungufu wa lymphocyte

  • Ongezeko la uzalishaji wa chembe sahani za damu

  • Maumivu

  • Maumivu ya maungo ya mwili

  • Mkojo kuwa na usaha

  • Ongezeko la vimengenya AST/ALT

  • Kukojoa damu

  • Kukohoa damu

  • Protini kwenye mkojo


Endapo umesahau kutumia rifapentine ufanyaje


Endapo umesahau kunywa dozi, kunywa mara pale utakapokumbuka, na endapo muda wa dozi nyingine umekaribia sana, acha dozi uliyosahau kisha subiri muda ufike na uendelee na dozi kama ulivyoshauriwa na daktari wako.

ONYO: Usitumie dawa yoyote bila ushauri wa daktari. Dawa zinaweza kuleta madhara mwilini na pia matumizi ya baadhi ya dawa pasipo ushauri na vipimo husababisha  vimelea kuwa sugu dhidi ya dawa hiyo.
ULY clinic inakushauri kuwasiliana na daktari wako unapotaka kuchukua maamuzi yoyote yanayohusu afya yako.
Wasiliana na daktari/Mfamasia wa ULY clinic kwa ushauri na Tiba au kuandikiwa dawa kwa kupiga simu au Kubonyeza Pata tiba chini ya tovuti hii.

Imeboreshwa,

23 Julai 2023 16:54:56

Rejea za mada hii:-

1. Overington JP, etal. How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

2. Imming P, et al. Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.

3. Williams DL, et al. Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 1998 Jul;42(7):1853-7.

4. Tupin A, et al. Resistance to rifampicin: at the crossroads between ecological, genomic and medical concerns. Int J Antimicrob Agents. 2010 Jun;35(6):519-23. doi: 10.1016/j.ijantimicag.2009.12.017.

5. FDA. Rifapentine. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf

6. Svensson EM, et al. Rifampicin and rifapentine significantly reduce concentrations of bedaquiline, a new anti-TB drug. J Antimicrob Chemother. 2015 Apr;70(4):1106-14. doi: 10.1093/jac/dku504.

7. Li AP, et al. Primary human hepatocytes as a tool for the evaluation of structure-activity relationship in cytochrome P450 induction potential of xenobiotics: evaluation of rifampin, rifapentine and rifabutin. Chem Biol Interact. 1997 Nov 6;107(1-2):17-30.

8. Shimokawa Y, et al. Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes. Biol Pharm Bull. 2015;38(9):1425-9. doi: 10.1248/bpb.b15-00313.

9. Williamson B, et al. Induction of influx and efflux transporters and cytochrome P450 3A4 in primary human hepatocytes by rifampin, rifabutin, and rifapentine. Antimicrob Agents Chemother. 2013 Dec;57(12):6366-9. doi: 10.1128/AAC.01124-13

10. Dooley KE, et al. Safety and pharmacokinetics of escalating daily doses of the antituberculosis drug rifapentine in healthy volunteers. Clin Pharmacol Ther. 2012 May;91(5):881-8. doi: 10.1038/clpt.2011.323.

11. Burman WJ, et al. Comparative pharmacokinetics and pharmacodynamics of the rifamycin antibacterials. Clin Pharmacokinet. 2001;40(5):327-41. doi: 10.2165/00003088-200140050-00002.

12. Aristoff PA, Garcia GA, Kirchhoff PD, Showalter HD: Rifamycins--obstacles and opportunities. Tuberculosis (Edinb). 2010 Mar;90(2):94-118. doi: 10.1016/j.tube.2010.02.001.

13. ULY CLINIC madhara rifapentine wakati wa ujauzito
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