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By ULY CLINIC

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Helicobacter Pylori Related Peptic Ulcer Disease 

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Introduction

 

Diagnostic Features 

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As of diagnostic criteria of  Gastroduodenal Ulcers (PUD) and Gastroesophageal Reflux Disease (GERD) together with evidence of 

  • Positive stool antigen test OR

  • Positive urease breath test OR

  • Positive urease test on  endoscopic  biopsy sample OR

  • Identification of the pathogen by histopathology examination 

 

Pharmacological Treatment

 

Triple therapy is indicated for complete eradication of the organism

 

  • Omeprazole (PO) 20mg twice daily Plus amoxycillin (PO) 1000mg twice daily 

AND

  • Metronidazole (PO) 400mg twice daily for 10–14 days

 OR

  • Lansoprazole (PO) 30mg twice daily 

AND  

  • Clarithromycin (PO) 500mg twice 

AND

  • Tinidazole (PO) 500mg twice daily for 10–14 days

OR        

 

  • Any combination of PPI + 2 antibiotics active for H. pylori 

 

Note: 

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  • H.pylori diagnostic tests should be repeated 3 months after 2weeks of triple therapy to confirm eradication. 

  • Refer to next level of care with adequate expertise and facility for cases refractory to conventional triple therapy or persistent of symptoms or new onset complications

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Updated on, 2.11.2020

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References

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1. STG

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