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Vitamin B6/Pyridoxine Deficiency

By ULYCLINIC

Introduction

Commonly presents as signs of peripheral neuropathy including:

• Tingling sensation
• Burning pain or numbness of the feet

Pyridoxine deficiency is related to:

• Malnutrition
• Alcoholism
• Isoniazid or combination TB therapy

Risk Factors

Signs and symptoms

Diagnostic criteria

Investigations

Managemet

  • Non-pharmacological

    Dietary advice:

    Increase intake of pyridoxine rich foods such as:

    • Liver, meat, fish and offal,
    • Wholegrain cereals, fortified breakfast cereals,
    • Peanuts, bananas, raw vegetables,
    • Walnuts and seeds, avocados, dried fruits,
    • Potatoes and baked beans.
  • Pharmacological

    For deficiency

    Children:

    • Pyridoxine 12.5mg (PO) daily for 3 weeks.

    Adults:

    • Pyridoxine, 25 mg (PO) daily for 3 weeks.

    For medicine-induced neuropathy

    Children

    • Pyridoxine, 50mg (PO) daily for 3 weeks.

    Adults

    • Pyridoxine, 200mg (PO) daily for 3 weeks.

    Then followed by:

    • Pyridoxine, 25mg (PO) daily as maintenance dose (for patients on TB therapy/isoniazid)

Prevention

Updated on,

20 Novemba 2020 11:21:01

References

    1. STG
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