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By ULY CLINIC Staff,

Peptic Ulcer disease(PUD) in Children


This refers to ulceration or mucosal breakdown involving the lower oesophagus, stomach and duodenum. They have in common the involvement of acid pepsin in the pathogenesis leading to disruption of mucosal integrity and active inflammation.
 

The common types of PUD include stomach and duodenal ulcers. Gastritis may involve the entire stomach (e.g. pan gastritis) or a region of the stomach (e.g. antral gastritis).
 

Diagnostic Criteria

 

  • Burning epigastric pain pre or post prandial

  • Plus endoscopic evidence of mucosal ulceration

Investigations

  • FBP

  • Screening for H. pylori

  • Oesophageal Gastro duodenoscopy (OGD)

Treatment:


Pharmacological treatment

 

  • Give Omeprazole 1mg/Kg once daily for six weeks OR

  • Esomeprazole PO 10 mg once daily for six weeks

For eradication of H. pylori
 

Triple therapy is indicated

  • Omeprazole PO 1mg/kg once daily for 14 days and

  • Metronidazole PO 7.5 mg/kg 12 hourly for 14 days and

  • Clarithromycin PO 7.5 mg/kg 12 hourly for 14 days. Then continue Either Omeprazole PO 1mg/Kg once daily for four weeks OR Esomeprazole PO 10 mg once daily for four weeks

 

Note:


If children have haematemesis and melaena refers to specialist 

Last updated on 14.09.2020

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References

  1. Tanzanian Standard treatment guideline for children 2017 edition page 78

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