Mwandishi:
Dkt. Mercy M, CO
Mhariri:
Dkt. Benjamin L, MD
Treprostinil ni moja kati ya dawa inayotumika kushusha shinikizo la juu la dmau kwenye mapafu.
Majina mengine ya Treprostinil
Majina mengine ya Treprostinil ni;
Remodulin
Orenitram
Tyvaso
Treprostinil ipo kundi gani la dawa?
Treprostinil ni dawa iliyo katika kundi la Prostacyclin analogs.
Dawa zilizo kundi moja na Treprostinil
Dawa zilizo kundi moja na Treprostinil ni ;
Epoprostenol
Iloprost
Fomu ya dawa ya Treprostinil
Dawa hii ipo katika fomu ya;
Solusheni kwaajiri ya sindano
Kidonge
Uzito wa dawa ya Treprostinil
Treprostinil ina uzito ufuatao;
Solusheni kwaajiri ya sindano
1mg/ml
2.5mg/ml
5mg/ml
10mg/ml
Vidonge
0.125mg
0.25mg
2.5mg
5mg
Treprostinil hutibu nini?
Hutumika kutibu shinikizo la damu (pressure) iliyojuu kwenye mapafu (pulmonary arterial hypertension)
Namna Treprostinil inavyoweza kufanya kazi
Prostaglandins zinapatikana kwenye tishu na majimaji ya mwilini na kupatanisha kazi za mwili. Treprostinil ni moja wapo katika familia ya prostaglandins ambazo hutoka kwenye arachidonic acid. Kazi kubwa ya Treprostinil ni kuzuia mkusanyiko wa platelet.
Ufyozwaji wa dawa
Kiwango cha dawa kinachoingia kwenye damu baada ya mtu kumeza dawa ni 100% na kinaonekana ndani ya masaa kumi baada ya mtu kutumia dawa.
Mwingiliano wa Treprostinil na chakula.
Dawa hii inaweza kutumika mtu akiwa amepata chakula au akiwa hajapata chakula.
Wagonjwa wasiopaswa kutumia Treprostinil
Wagonjwa wenye mzio wa Treprostinil ni;
Wagonjwa wenye mzio wa dawa jamii ya prostacyclin analogs.
Utoaji taka wa Treprostinil mwilini
Asilimia sabini na tisa (79%) ya dawa hutolewa kwa njia ya mkojo na asilimia kumi na tatu (13%) hutolewa kwa njia ya haja kubwa.
Matumizi ya Treprostinil kwa mama mjamzito
Hakuna tafiti zinazoonesha madhara ya dawa hii kwa mama mjamzito na mtoto aliye tumboni hivyo taadhari inatakiwa kuchukuliwa wakati mama anatumia dawa hii.
Matumizi ya Treprostinil mama anayenyonyesha
Hakuna tafiti zinazoonesha madhara ya dawa hii kwa mama anayenyonyesha, kwa mtoto na katika uzalishwaji wa maziwa hivyo kimoja wapo kati ya mtoto kunyonya na mama kutumia dawa inatakiwa viangaliwe kulingana na uhitaji .
Dawa zenye muingiliano na Treprostinil
Dawa zenye mwingiliano mkali na hivyo kutofaa kutumika pamoja na Treprostinil ni Lofexidine
Dawa zinazoweza kutumika na Treprostinil chini ya uangalizi
Aldesleukin
Amifostine
Candesartan
Cannabidiol
Carbidopa
Dabigatran
Dichlorphenamide
Eluxadoline
Epoprostenol
Eprosartan
Fenoldopam
Fish oil triglycerides
Green tea
Hydralazine
Ibrutinib
Iloprost
Irbesartan
Levodopa
Losartan
Maraviroc
Mifepristone
Minoxidil
Olmesartan
Sacubitril/valsartan
Stiripentol
Tecovirimat
Telmisartan
Teriflunomide
Valsartan
Xipamide
Dawa zenye mwingiliano mdogo na Treprostinil;
Acebutolol
Amlodipine
Atenolol
Benazepril
Bendroflumethiazide
Betaxolol
Bisoprolol
Bosentan
Captoprii
Chlorothiazide
Chlorthalidone
Eplerenone
Epoprostenol
Furosemide
Guanfacine
Hydralazine
Hydrochlorothiazide
Iloprost
Imidapril
Indapamide
Isradipine
Ketanserin
Methyclothiazide
Metolazone
Moxonidine
Nadolol
Nifedipine
Nisoldipine
Penbutolol
Perindopril
Phenoxybenzamine
Phentolamine
Pindolol
Prazosin
Propranolol
Quinapril
Ramipril
Reishi
Shepherd's purse
Silodosin
Sotalol
Spironolactone
Terazosin
Timolol
Tizanidine
Torsemide
Trandolapril
Triamterene
Verapamil
Maudhi madogo ya Treprostinil
Maumivu ya tumbo
Kichefuchefu
Maumivu ya kichwa
Taya kuuma
Vipele
Maumivu ya misuli
Kichefuchefu
Maumivu ya mgongo
Vasodilation
Magonjwa ya ngozi
Cellulitis
Shinikizo la damu kuwa chini
Mapigo ya moyo kuwa juu
Kizunguzungu
Mwili kuvimba
Misuli kukaza
Maumivu ya mifupa
Mwili kuchoka
Ufanye nini endapo utasahau kutumia dozi yako?
Kama umesahau kutumia dozi yako tumia mara pale utakapokumbuka, kama muda wa dozi inayofata umekaribia usimeze dozi uliyosahau endelea na dozi inayofuata kwa muda uliopangiwa na daktari. Usimeze dozi mbili kufidia uliyosahau.
13 Juni 2023 19:18:46
Dawa Treprostinil
Imeboreshwa,
29 Oktoba 2021 13:55:50
Dawa yoyote ni sumu, usitumie dawa pasipo ushauri wa daktari kuepuka madhara kwenye ogani mbalimbali kama figo na ini. Matumizi ya dawa pasipo ushauri wa daktari unaweza kusababisha madhara na usugu wa vimelea vya maradhi kwenye dawa.
ULY CLINIC inakushauri siku zote uwasiliane na daktari wako kwa ushauri na tiba kabla ya kuchukua hatua yoyote ile baad aya kusoma makala hii.
Kupata ushauri zaidi na tiba kutoka kwa daktari wa ULY CLINIC bofya Mawasiliano yetu au Pata tiba.
Rejea za mada hii:
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Bax RP, et al. The pharmacokinetics of meropenem in volunteers. J Antimicrob Chemother. 1989 Sep;24 (Suppl A):311–320.
Burman LA, et al. Pharmacokinetics of meropenem and its metabolite ICI 213,689 in healthy subjects with known renal metabolism of imipenem. J Antimicrob Chemother. 1991 Feb;27(2):219–224.
Christensson BA, et al. Pharmacokinetics of meropenem in subjects with various degrees of renal impairment. Antimicrob Agents Chemother. 1992 Jul;36(7):1532–1537.
DAVIES DF, SHOCK NW. Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J Clin Invest. 1950 May;29(5):496–507.
Douglas JG, et al. The pharmacokinetics of cefuroxime in the elderly. J Antimicrob Chemother. 1980 Jul;6(4):543–549.
Granerus G, et al. Reference values for 51Cr-EDTA clearance as a measure of glomerular filtration rate. Scand J Clin Lab Invest. 1981 Oct;41(6):611–616.
Harrison MP, et al. The disposition and metabolism of meropenem in laboratory animals and man. J Antimicrob Chemother. 1989 Sep;24 (Suppl A):265–277.
Jones RN, et al. In-vitro studies of meropenem. J Antimicrob Chemother. 1989 Sep;24 (Suppl A):9–29.
Krutzén E, et al. Plasma clearance of a new contrast agent, iohexol: a method for the assessment of glomerular filtration rate. J Lab Clin Med. 1984 Dec;104(6):955–961.
Ljungberg B, et al. Pharmacokinetics of antimicrobial agents in the elderly. Rev Infect Dis. 1987 Mar-Apr;9(2):250–264.