Hodgkin’s disease (HD)
Introduction
Nodular lymphocyte predominant Hodgkin lymphoma–NLPHL
Classical Hodgkin lymphoma–CHL, which is sub–divided into:
• Nodular sclerosis classical Hodgkin lymphoma–NSHL
• Mixed cellularity classical Hodgkin lymphoma–MCHL
• Lymphocyte–rich classical Hodgkin lymphoma–LRCHL
• Lymphocyte–depleted classical Hodgkin lymphoma–LDHL
Signs and Symptoms
Diagnostic criteria
• Enlarged painless lymph nodes in the neck or elsewhere
• B symptoms (weight loss, night sweats, and fever), pruritus, alcohol induced pain, general condition, throat, lymph nodes (site, number, size, consistency, mobility, matting), respiratory system, abdomen (liver, spleen, other masses), bone tenderness
Investigation
• CXR
• CT Scan of neck, chest, abdomen and pelvis
• FBC
• ESR
• Bone marrow aspirate and biopsy (Not required in Stage I or II A)
• Biopsy histological diagnosis
• Liver function profile
• Renal function profile
• LDH
Treatment
-
Pharmacological
- Chemotherapy aims at cure for any stage of the disease. It is indicated in Stages II–IV. Current standard regimen is ABVD which include combination of the following drugs:
• Adriamycin IV 25 mg/m2
AND
• Bleomycin IV 10 IU/m2
AND
• Vinblastine IV 6 mg/m2
AND
• Dacarbazine IV 375 mg/m2, all given on day 1 & 15, every 4 weeks for 4–8 cycles.
Radiotherapy: can either be; involved field RT or mantle or inverted Y depending on site of disease: 1.8–2Gy/fr for 30–40Gy total dose.
-
Non-pharmacological
-
Prevention
Updated on,
5 Novemba 2020 12:45:05
References
1.STG