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Rabies is an acute viral infection of the central nervous system that affects all mammals and is transmitted to man by animal bites via infected secretions, usually saliva.   

Diagnostic Criteria

  • Early or prodromal clinical features of the disease include apprehensiveness, restlessness, fever, malaise and headache  

  • The late features of the disease are excessive motor activity and agitation, confusion, hallucinations, excessive salivation, convulsions and hydrophobia   

Pharmacological Treatment

Local wound therapy:-Wash wound thoroughly with water and soap and repeat process with 10% Povidone iodine; prevent secondary bacterial infection

For Prophylactic wound therapy that has lasted less than 8 hours  

  • Amoxicillin-clavulanic acid 500mg/125mg (PO) 8 hourly for 5 days 


For Infected wounds and wounds older than 24 hourly, 

  • Amoxicillin-clavulanic acid 500mg/125mg (PO) 8 hourly for 5 days    


  • Clindamycin 150–300 mg every 6 hourly for 5 days  


  • Ciprofloxacin (adults) 500mg 12 hourly for 5 days   


  • Trimetroprim/Sulphamethoxazole (children) 120-480mg 12 hourly for         5 days


Passive Immunization 

  • Anti-rabies human immunoglobulin 20 IU/kg half the dose given   parenterally and the other half injected into and around the wound 


Active Immunization 

  • Human Diploid Cell Vaccine (HDCV) 1ml I.M on day 0, 3, 7, 14 and 28.In addition, patients should receive rabies immune globulin with the first dose(day 0)


Tetanus toxoid vaccine click  on Tetanus

Updated on, 31.10.2020


1. STG 

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