By ULY CLINIC

Rabies

Introduction

Rabies is an acute viral infection of the central nervous system that affects all mammals and is transmitted to man by animal bites via infected secretions, usually saliva.

Diagnostic Criteria

Early or prodromal clinical features of the disease include apprehensiveness, restlessness, fever, malaise and headache
The late features of the disease are excessive motor activity and agitation, confusion, hallucinations, excessive salivation, convulsions and hydrophobia

Pharmacological Treatment

Local wound therapy:-Wash wound thoroughly with water and soap and repeat process with 10% Povidone iodine; prevent secondary bacterial infection

For Prophylactic wound therapy that has lasted less than 8 hours

Amoxicillin-clavulanic acid 500mg/125mg (PO) 8 hourly for 5 days

For Infected wounds and wounds older than 24 hourly,

Amoxicillin-clavulanic acid 500mg/125mg (PO) 8 hourly for 5 days

AND

Clindamycin 150–300 mg every 6 hourly for 5 days

AND

Ciprofloxacin (adults) 500mg 12 hourly for 5 days

Trimetroprim/Sulphamethoxazole (children) 120-480mg 12 hourly for 5 days

Passive Immunization

Anti-rabies human immunoglobulin 20 IU/kg half the dose given parenterally and the other half injected into and around the wound

Active Immunization

Human Diploid Cell Vaccine (HDCV) 1ml I.M on day 0, 3, 7, 14 and 28.In addition, patients should receive rabies immune globulin with the first dose(day 0)

Tetanus toxoid vaccine click on Tetanus

Updated on, 31.10.2020

References

1. STG

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