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Hepatocellular Carcinoma
Introduction
Associated with chronic Hepatitis B infection
Management
Lobectomy where feasible but in the abscess of regular health check-up almost all patients present with advanced disease hence palliative therapy.
Signs and Symptoms
Diagnostic criteria
• An arterial bruit and ascites may be present
• Right upper abdominal swelling and pain often associated with weight loss, fever, jaundice
Investigation
• FBC, LFTs, biochemistry, serum alpha feto protein, HBsAg, HBcore antibody,partial thromboplastin time (PTT)
• CXR, Abdominal and pelvic USS or CT Scan
• Biopsy or FNAC of the liver
Staging: TNM
Treatment
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Pharmacological
- Single agent doxorubicin is used for palliation
• Doxorubicin IV 60 mg/m2 Day1 given every 3 weeks for 4–6 cycles
Prevention: Vaccination for Hepatitis B
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Non-pharmacological
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Prevention
Updated on,
5 Novemba 2020 11:27:38
References
1.STG
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